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A Matter of Structure
Before scientists can design drugs to fight diseases, they need to know the surface shape and interior geometry of proteins. A Penn team from SAS and PennMed has resolved the molecular structure of the elusive lac repressor. On the team, below,are Mitchell Lewis of Biochemistry & Biophysics/Med (rear), Helen Pace, Michele Kercher, and Ponzy Lu of SAS Chemistry. More information.
On the team's computer-generated graphics, colors identify individual monomors and deoxyoligonucleotides (above, lower picture) so that when an image's orientation is changed--to the "overhead" view (above, top picture), for example--scientists can see that the upper two fragments of eoxyoligonucleotide are separated in space and do not interact in the tetramer. Photo by Tommy Leonardi
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