Daniel P. Kelly, a renowned cardiac metabolism expert, joined Penn Medicine in August as the director of the Penn Cardiovascular Institute (CVI), a multi-disciplinary group of researchers and physicians dedicated to scientific discoveries and medical breakthroughs in heart and vascular care. He will lead a cross-disciplinary team of basic, translational and clinical researchers, leveraging laboratory research to develop the next generation of therapies for cardiovascular disease.
Dr. Kelly joined Penn from Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona near Orlando, where he began as the Institute’s founding scientific director in 2008. Under his leadership, the SBP-Lake Nona’s research program grew significantly, the organization established collaborative partnerships with academic institutions, industry and health systems, and became a transformational driver in the development and expansion of science and medicine in Florida.
As a physician-scientist, Dr. Kelly has spent the majority of his career focusing on the metabolic origins of heart muscle diseases, specifically looking at the connection between gene regulatory circuits and complex acquired cardiovascular and metabolic diseases. In an effort to discover new therapeutic targets and biomarkers, the Kelly laboratory has focused on the use of genomic, proteomic, lipidomic and metabolomic profiling of animal disease models and in human disease phenotypes to examine the pathways that regulate heart and skeletal muscle energy metabolism in search of new therapeutic targets.
“We are thrilled to recruit a leader of Dr. Kelly’s caliber to Penn, and we are confident that under his leadership, Penn will become recognized as the nation’s leading cardiovascular research center,” said Michael S. Parmacek, the Frank Wister Thomas Chair of Medicine in the Perelman School of Medicine. “We are especially excited for the role Dr. Kelly’s particular expertise will play in catalyzing programs bridging the Penn CVI and Penn’s Institute of Diabetes, Obesity and Metabolism.”
In addition to his research and academic work, Dr. Kelly has been involved with a number of professional organizations, including the American Heart Association, the American College of Cardiology, the International Society for Heart Research and the Association of University Cardiologists. He serves as an associate editor for the Journal of Clinical Investigation and the Journal of the American College of Cardiology: Basic to Translational Science, and is on the editorial board for Nuclear Receptor Signaling.
After earning his bachelor’s in biology from the University of Illinois, Dr. Kelly earned his medical degree at the University of Illinois College of Medicine. In St. Louis, he did his residency at Barnes Hospital and a postdoctoral research fellowship and a clinical cardiology fellowship at the Washington University School of Medicine. He spent the majority of his career in the Midwest, before moving to Florida to lead the evolution of the SBP-Lake Nona site.