Optical Imaging and Micromanipulation Facility at the Laboratory for Research on the Structure of Matter:
This facility is under construction and will meet the needs of the Liquid Crystals, Colloids and Emulsions IRG and the Biomolecular Materials IRG. It contains:
- An optical work station that includes fluorescence microscopy, light scattering, and laser tweezers.
- A confocal microscopy facility consisting of two microscope bases (Leica DMR and DM/IR) and a Noran Oz confocal head.
- A force measuring laser line-tweezer system based on a Zeiss Axiovert 135.
- A Near-Field Scanning Optical Microscope (NSOM) mounted on an Inverted Optical stage which enables the coupling of other capabilities such as Laser Tweezers to the instrument.
- A combination STM/AFM microscope
There are also confocal microscope facilities at the Department of Cell and Developmental Biology (School of Medicine) and the Department of Bioengineering (School of Engineering and Applied Science).
For more information on Optical Imaging, please visit the following sites:
Institute for Medicine and Engineering, http://www.med.upenn.edu/ime/
Department of Bioengineering, http://www.seas.upenn.edu/be/
The Laboratory for Research on the Structure of Matter (LRSM), http://www.lrsm.upenn.edu/
The Pennsylvania Muscle Institute,http://www.med.upenn.edu/~pmi/
~ return to top ~
Biomedical Imaging at the Department of Radiology
Penn's interdisciplinary research in Biomedical Imaging centers around the School of Medicine's Department of Radiology, and spans investigators from many other departments across campus. Since 1990 the Department has held the number one ranking nationally in number and dollars of NIH research grants awarded. The Department continues its several research agreements with Industry, including General Electric, Bracco, Dupont, and Phillips, as well as its collaboration with Vital Imaging on 3D and virtual endoscopic image displays.
Interdisciplinary research in Biomedical Imaging is conducted in various sections of the Radiology Department:
Department of Radiology - Highlights of research accomplishments for 1998:
The section of Radiophamaceutical Chemistry achieved the development of the first CNS DAT binding site specific imaging agent [99mTc]TRODAT-1. This agent shows promise as a diagnostic tool for Parkinson's disease and other CNS neurodegenerative diseases, for which a reduction of dopamine neurons is indicated. A paper on in-vivo characterization of this agent received the Springer award for the best basic science paper for the European Journal of Nuclear Medicine.
- Breast Imaging
- Cardio-Thoracic Imaging
- Computed Tomography (Body)
- Gastrointestinal Radiology
- Genitourinary Radiology
- Interventional Radiology
- Magnetic Resonance Imaging
- Medical Image Processing Group
- Metabolic Imaging
- Musculoskeletal Imaging
- Nuclear Medicine
- Pendergrass Diagnostic Imaging Laboratory
- Physics (Diagnostic Imaging)
- Physics (PET)
The Interventional Radiology section began an important collaboration with Vascular Surgery to develop minimally invasive approaches for placing intravascular (primarily aortic and iliac) shunts. This approach will revolutionize the treatment of intravascular lesions (primarily aneurysms and stenosis) and, since it requires advanced skills in both surgery and radiology, demands a high degree of collaboration between the two departments. Judging by objective data regarding scientific papers and presentations, the section has a dominant role at the two major scientific venues in our field -- the Radiologic Society of North America and the Society of Cardiovascular and Interventional Radiology.
The MRI section continues to diversify its research efforts. We have successfully implemented imaging of human sinuses and lungs using hyperpolarized helium. We have now applied this to patients with emphysema with the expectation that this will become part of the standard work-up for patients being considered for lung reduction surgery. Our work in MRI imaging of the Breast continues with ever increasing success. On the basis of this we initiated several multi-center trials to increase the number of patients with the goal of bringing this into clinical use as soon as possible.
Our efforts in functional MRI (fMRI) were ported to the 4T MRI system with increased resolution and enhanced signal to noise. This allows experiments into more sophisticated studies of cognition, with the potential for real time, whole brain studies. New 3D, motion insensitive, whole brain perfusion techniques were developed that do not require injection of contrast agents. This technique is ideally suited for the emergency evaluation of patients with acute stroke in order to determine whether they are suitable candidates for thrombolytic therapy.
Dr. Kundel continues as the Principal investigator of a Program Project Grant P01-CA5311 called Modeling and Evaluating Image Management Systems. It is a multidisciplinary effort among the Departments of Radiology, Medicine, Epidemiology and Emergency Medicine in the Medical School and the Operations and Information Management Department of the Wharton School. The clinical test bed is the Emergency Department and the objective is to study how the introduction of digital imaging and digital management systems affects diagnostic accuracy, workflow efficiency, and operation costs.
More information on the Radiology Department at Penn can be found at http://www.rad.upenn.edu/Dept.html
~ return to top ~