School of Medicine
Association of Senior and Emeritus Faculty (ASEF)


A luncheon sponsored by ASEF will be held at 12 noon on Monday, October 13, 2008. Please join us for an excellent lunch with colleagues and listen to an interesting speaker. RSVP to asef@mail.med.upenn.edu, as seating is LIMITED.

Location: Lenape Room in University Club, 3611 Walnut Street, Second Floor.

Professor Yvonne Paterson will give a talk entitled:

Active Immunotherapy for Cancer Using a Live Recombinant Vector

There has been a great deal of interest in the past decade in harnessing the immune system to fight cancer by targeting the immune response to antigens expressed by tumors, a strategy colloquially know as "cancer vaccines". In our laboratory, we are using a facultative intracellular bacterium, Listeria monocytogenes, for this purpose, which has the unusual ability to live and grow in the cytoplasm of the cell. Our laboratory was the first to show that this bacterium could be used to target antigens to the immune system with the induction of cytotoxic T cells. We are applying this technology in the development of cancer vaccines that result in the induction of potent cell mediated immunity that can eliminate established macroscopic tumors even in the face of profound immune tolerance to the tumor-associated antigen. In other studies, we have discovered that fusing an antigen to some bacterial proteins enhances its immunogenicity. This finding opens up novel, and perhaps safer, avenues to cancer immunotherapy. Cancers to which we are directing our various technologies currently include cervical cancer, breast cancer, lung cancer, melanoma and lymphoma. The first application in humans took place last year in a phase I trial for advanced cervical cancer.

Luncheon Lite (Soup and sandwich or soup and salad)..................$7.50

Full Lunch...................................................................................$10.25

ASEF luncheons are organized by Nick Kefalides (Infectious Diseases, School of Medicine).


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