Center for Interdisciplinary Research on Nicotine Addiction

The Center for Interdisciplinary Research on Nicotine Addiction (CIRNA) at Penn’s School of Medicine, formally known as the Transdisciplinary Tobacco Use Research Center, focuses on interdisciplinary projects that are aimed at increasing the scientific knowledge of the effects of nicotine withdrawal. It also works to advance new models for medication development. The Center offers smokers the opportunity to participate in a variety of smoking cessation research programs and clinical trials, and compensates many of them for their time and travel. Read a related story about smoking cessation at Penn.


In this edition of By The Numbers, we kick the habit with CIRNA.


Length, in weeks, of the Effects of Medication on Mental Performance study, which tests the effects of the drug tolcapone on how the brain works after 24 hours of not smoking.


Hours participants must remain smoke-free as part of the Effects of Nicotine on Brain Opioid Receptors study, which compares brain changes associated with an injection of nicotine or a placebo after remaining smoke-free.


Cost to participate in the Brain Mechanisms Underlying Smoking Relapse program, which gives eligible smokers individual training skills to quit smoking with an expert smoking cessation counselor.


Length, in days, of the Maintenance Therapy Nicotine Patch program, in which eligible participants are randomly assigned to wear a 21 mg nicotine patch for eight weeks, 24 weeks or 52 weeks. All participants receive counseling for a full year.


Number of Public Service Announcements (PSAs) that eligible participants must view as part of the Effects of Smoking Cues in Anti-Tobacco PSAs study. The program examines the effects of anti-tobacco PSAs on smoking urges, message procession, persuasion and adult smoking behavior. Physiological (heart rate and palm sweat) reactions and eye tracking are measured while participants view the PSAs. To learn more about all of the Center’s clinical trials, call 1-877-513-QUIT.

Originally published on April 21, 2011