Penn Medicine: Genomewide Screen of Learning in Zebrafish Identifies Enzyme Important in Neural Circuit

Researchers at the Perelman School of Medicine at the University of Pennsylvaniadescribe the first set of genes important in learning in a zebrafish model in the journal Neuron this week. “Using an in-depth analysis of one of these genes, we have already revealed an important relevant signaling pathway,” says senior author Michael Granato, PhD, a professor of Cell and Developmental Biology. “The proteins in this pathway could provide new insights into the development of novel pharmacological targets.”

Penn Scientists Describe the Function of an Enzyme Critical to Male Fertility

In a study published in the journal Genes and Development, University of Pennsylvania researchers have filled in details of how an enzyme, through interactions with a network of nearly two dozen other genes, protects the integrity of the germ line by giving rise to a class of RNA molecules that are essential to sperm development.

Penn Vet Researchers Identify Effective Treatment for Niemann Pick Type C

A study coming out in Science Translational Medicine and led by University of Pennsylvania School of Veterinary Medicine researchers has shown that cats with the rare disease Niemann Pick type C — which mirrors the human version of the disease — show vast improvements when treated with a compound called cyclodextrin.



Penn in the news

We Need to Unlock the Brain’s Secrets – Ethically March 26, 2015 | Scientific American

President Amy Gutmann, Presidential Bioethics Commission chair, writes about three key areas of ethical concern in neuroscience research and application.

Should We Give Fetuses Painkillers Before We Abort Them? March 26, 2015 | Washington Post

Elaina Lin of the Perelman School of Medicine shares her perspective on fetal surgery and fetal pain research.

Gene Counselors Expect Resurgence of ‘Jolie Effect’ March 26, 2015 | Nature.com

Katherine Nathanson of the Perelman School of Medicine is quoted about BRCA testing.

Shaken Baby Syndrome: A Disputed Diagnosis Imprisons Parents March 20, 2015 | Washington Post

Susan Margulies of the Perelman School of Medicine speaks on the difficulty of studying brain injuries in infants.

Experts Back Angelina Jolie Pitt in Choices for Cancer Prevention March 24, 2015 | New York Times

Susan Domchek of the Perelman School of Medicine is quoted about cancer prevention options and Penn’s Basser Research Center is mentioned.

From the Penn Current