Andrew Maidment of the School of Medicine comments on the effects of the Chernobyl disaster and how it might be able to predict the effects of the recent disaster in Japan.
Perelman School of Medicine
Researchers at the University of Pennsylvania School of Medicine have devised a totally new and far more efficient way of generating induced pluripotent stem cells (iPSCs), immature cells that are able to develop into several different types of cells or tissues in the body. The researchers used fibroblast cells, which are easily obtained from skin biopsies, and could be used to generate patient-specific iPSCs for drug screening and tissue regeneration.
Two reports by addiction researchers at the University of Pennsylvania School of Medicine and the National Institute on Drug Abuse show a drastic shift in prescribing patterns impacting the magnitude of opioid substance abuse in America. The reports, published in JAMA, recommend a comprehensive effort to reduce public health risks while improving patient care, including better training for prescribers, pain management treatment assessment, personal responsibility and public education.
Gerard Schellenberg of the School of Medicine comments on his study of Alzheimer’s.
Researchers at the University of Pennsylvania School of Medicine may have found a way to turn an adaptive cellular response into a liability for cancer cells. When normal cells are starved for food, they chew up existing proteins and membranes to stay alive. Cancer cells have corrupted that process, called autophagy, using it to survive when they run out of nutrients and to evade death after damage from chemotherapy and other sources.
Each year, more than 100,000 patients in the U.S. undergo implantation of a new implantable cardioverter defibrillator (ICD) for heart rhythm abnormalities. This number constitutes a 20-fold increase over the last 15 years. Current medical guidelines advocate discussion of end of life care of these medical devices, including deactivation, but many patients may not understand their options.
Arthur Caplan of the School of Medicine contributes his perspective on Arizona’s strategies to balance its budget.