Susan Domchek of the Perelman School of Medicine says that the study does not “resolve the question of what the risk is to someone with no family history and a mutation.”
Perelman School of Medicine
One of the goals of genome sequencing is to identify genetic mutations associated with increased susceptibility to disease. Yet by and large these discoveries have been made in people of European or Asian ancestry, resulting in an incomplete picture of global genetic variation in disease vulnerability.
Penn Study Shows Better Outcomes for Sepsis Patients Treated in Hospitals with Higher Volume of Cases
Patients with sepsis, one of the most time-sensitive and hard-to-detect illnesses in medicine, are more likely to survive the life-threatening condition when treated at a hospital that sees a higher volume of sepsis cases.
Ezekiel Emanuel of the Perelman School of Medicine and the Wharton School is quoted from his book Reinventing American Health Care.
The Perelman School of Medicine’s Mariell Jessup and Lee Goldberg comment on a study on an experimental drug for heart failure.
Since 2005 the University of Pennsylvania‘s Penn Integrates Knowledge program has brought to campus exceptional faculty members whose research and teaching exemplify the integration of knowledge across disciplines.
A Penn Medicine-developed drug has received orphan status in Europe this week for the treatment of paroxysmal nocturnal hemoglobinuria (PNH), a rare, life-threatening disease that causes anemia due to destruction of red blood cells and thrombosis.
Treating the rare disease MPS I is a challenge. MPS I, caused by the deficiency of a key enzyme called IDUA, eventually leads to the abnormal accumulation of certain molecules and cell death.
On average, states allowing the medical use of marijuana have lower rates of deaths resulting from opioid analgesic overdoses than states without such laws. Opioid analgesics, such as OxyContin, Percocet and Vicodin, are prescribed for moderate to severe pain, and work by suppressing a person’s perception of pain.