PHILADELPHIA -– Researchers at the University of Pennsylvania have developed a new electronic method for detecting microRNA isolated from living cells. MicroRNAs are a class of small biomolecules that control gene expression into proteins, the “workers” of the cell. MicroRNAs act by binding to specific messenger RNAs that code for proteins, and, by doing so, inhibit protein synthesis.
Perelman School of Medicine
When most genes are transcribed, the nascent RNAs they produce are not quite ready to be translated into proteins - they have to be processed first. One of those processes is called splicing, a mechanism by which non-coding gene sequences are removed and the remaining protein-coding sequences are joined together to form a final, mature messenger RNA (mRNA), which contains the recipe for making a protein.
John D. Kelly of the School of Medicine discusses an FDA recall of a medical device.
A school-based, six-session program targeting sexual risk behaviors has proven effective in reducing rates of self-reported unprotected sex and sex with multiple partners among South African sixth-graders, according to a report in the October issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.
Taking a cue from the world of business-performance experts and baseball talent scouts, Penn Medicine translational medicine researchers are among the first to find a way to measure the productivity of collaborations in a young, emerging institute. They published their findings the most recent issue of Science Translational Medicine.
Finding a drug that can cross the blood-brain barrier is the bane of drug development for Alzheimer’s disease and other neurological disorders of the brain. A new Penn study, published this week in the Journal of Neuroscience, has found and tested in an animal model of Alzheimer’s disease a class of drug that is able to enter the brain, where it stabilizes degenerating neurons and improves memory and learning.
Arthur Caplan of the School of Medicine comments on reality in a medical-sitcom script.