Perelman School of Medicine

Kidney Disease Is Parasite-Slaying Protein's Downside

July 16, 2010

Sarah Tishkoff of the School of Medicine and the School of Arts and Sciences discusses “Jekyll-and-Hyde genetic variations."

Article Source: Science

Mirror, Mirror: Putting More Protection in Sunscreen

July 21, 2010

William James of the School of Medicine discusses sunscreen’s effectiveness.

Article Source: Philadelphia Inquirer

Taking an Alternative Path in Fighting the Disease

July 16, 2010

John Trojanowski and Virginia Lee of the School of Medicine are cited for their innovative Alzheimer’s research.

Article Source: New York Times

Sleep? Too Busy in Bed

July 16, 2010

James Findley and Philip Gerhman of the School of Medicine and Penn Sleep Center say the brain associates one’s bed with sleep.

Article Source: Philadelphia Inquirer
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Media Contact: | | July 19, 2010

Penn Researchers Discover New Role for Master Regulator in Cell Metabolism, Response to Stress

AMP-activated protein kinase, or AMPK, is a master regulator protein of metabolism that is conserved from yeast to humans. When a cell is low on fuel, AMPK shuts down processes that use energy and turns on processes that produce energy.

Biologists have been studying how AMPK works for several decades and know that once it is activated, AMPK turns on a large number of genes by passing the "make more energy" message through numerous signaling cascades in the cell. What was not known, until now, was that AMPK also works via an epigenetic mechanism to slow down or stop cell growth.

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Media Contact:Karen Kreeger | karen.kreeger@uphs.upenn.edu | (215) 349-5658 July 19, 2010

Rescuing Fruit Flies from Alzheimer’s Disease

Investigators have found that fruit fly (Drosophila melanogaster) males -- in which the activity of an Alzheimer’s disease protein is reduced by 50 percent -- show impairments in learning and memory as they age. What’s more, the researchers were able to prevent the age-related deficits by treating the flies with drugs such as lithium, or by genetic manipulations that reduced nerve-cell signaling.

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Better Living Through Implants

July 15, 2010

Brian Litt of the School of Medicine is highlighted for his work on brain implant effectiveness.

Article Source: PC World

Health Care's "Consumer Reports": Helping Doctors Find the Best Treatments for You

July 13, 2010

Craig Umscheid of the School of Medicine and the Penn Medicine's Center for Evidence-Based Practice authors an op-ed on the consumer’s role in doctors’ prescription choices.

Article Source: Huffington Post

Editorial: Another Plus for DHS

July 14, 2010

Cindy Christian of the School of Medicine and Safe Place, the Center for Child Protection and Health, is praised for her child advocacy in light of her appointment as child-abuse expert at the Philadelphia Department of Human Services.

Article Source: Philadelphia Inquirer

The Bigger Your Head, the Better Your Memory?

July 14, 2010

Steven Arnold of the School of Medicine and Penn Memory Center discusses a study linking head size to memory.

Article Source: MSNBC