Women who have inherited mutations in the BRCA1 or BRCA2 (BRCA1/2) genes have substantially elevated risks of developing breast and ovarian cancer. A study that will appear in the September 1 issue of The Journal of the American Medical Association (JAMA) reports that women with these inherited mutations who have had a prophylactic mastectomy or salpingo-oophorectomy (removal of the fallopian tubes and ovaries) had an associated decreased risk of breast cancer and ovarian cancer.
Perelman School of Medicine
Leslie Shaw of the School of Medicine is cited for his research on an early Alzheimer’s diagnostic tool.
Benjamin Abella of the School of Medicine discusses hypothermia’s clinical uses in treating cardiac arrest.
Adrian Raine of the School of Arts and Sciences and the School of Medicine is cited for his neurological research on psychopathic behavior.
By comparing two species of ants, Shelley Berger, PhD, the Daniel S. Och University Professor at the University of Pennsylvania, and colleagues Danny Reinberg, PhD, New York University, and Juergen Liebig, PhD, Arizona State University, have established an important new avenue of research for epigenetics -- the study of how the expression or suppression of particular genes affects an organism's characteristics, development, and even behavior.
Despite the fact that an estimated 25 million patients per year in the U.S. undergo surgeries using general anesthesia, scientists have only been able to hypothesize exactly how anesthetics interact with the central nervous system. They previously thought that the processes of “going under” and waking up from anesthesia affected the brain in the same way.
Male infertility is a common medical problem, affecting millions of men in the United States annually. Its causes include an inability to make productive sperm. Now, using yeast as a model organism, researchers at the University of Pennsylvania School of Medicine are beginning to identify the molecular signals that could in part underlie that problem.
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