Sarah Tishkoff of the School of Medicine and the School of Arts and Sciences discusses “Jekyll-and-Hyde genetic variations."
Perelman School of Medicine
William James of the School of Medicine discusses sunscreen’s effectiveness.
John Trojanowski and Virginia Lee of the School of Medicine are cited for their innovative Alzheimer’s research.
AMP-activated protein kinase, or AMPK, is a master regulator protein of metabolism that is conserved from yeast to humans. When a cell is low on fuel, AMPK shuts down processes that use energy and turns on processes that produce energy.
Biologists have been studying how AMPK works for several decades and know that once it is activated, AMPK turns on a large number of genes by passing the "make more energy" message through numerous signaling cascades in the cell. What was not known, until now, was that AMPK also works via an epigenetic mechanism to slow down or stop cell growth.
Investigators have found that fruit fly (Drosophila melanogaster) males -- in which the activity of an Alzheimer’s disease protein is reduced by 50 percent -- show impairments in learning and memory as they age. What’s more, the researchers were able to prevent the age-related deficits by treating the flies with drugs such as lithium, or by genetic manipulations that reduced nerve-cell signaling.
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Craig Umscheid of the School of Medicine and the Penn Medicine's Center for Evidence-Based Practice authors an op-ed on the consumer’s role in doctors’ prescription choices.
Cindy Christian of the School of Medicine and Safe Place, the Center for Child Protection and Health, is praised for her child advocacy in light of her appointment as child-abuse expert at the Philadelphia Department of Human Services.