Penn Medicine researchers have begun a new immunotherapy trial with the “checkpoint inhibitor” known as pembrolizumab in patients with oligometastatic lung cancer—a state characterized by a few metastases in a confined area—who have completed conventional treatments and are considered free of active disease but remain at a high risk for recurrence.
Peripheral nerve injury (PNI) is a common consequence of traumatic injuries, wounds caused by an external force or an act of violence, such as a car accident, gun shot or even surgery. In those injuries that require surgical reconstruction, outcomes can result in partial or complete loss of nerve function and a reduced quality of life. But, researchers at Penn Medicine have demonstrated a novel way to regenerate long-distance nerve connections in animal models using tissue-engineered nerve grafts (TENGs).
A new discovery shows how a simple intervention—self-affirmation—can open our brains to accept advice that is hard to hear.
Fifteen years ago, the name “Aiden” was hardly on the radar of Americans with new babies. It ranked a lowly 324th on the Social Security Administration’s list of popular baby names. But less than a decade later, the name became a favorite, soaring into the top 20 for five years and counting.
By Sarah Welsh
Women in their late thirties and forties who have trouble sleeping are more than three times more likely to suffer sleep problems during menopause than women who have an easier time getting shut-eye, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Penn Study Reveals Possible Therapeutic Target for Common, But Mysterious Brain Blood Vessel Disorder
Tens of millions of people around the world have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations (CCMs). These abnormal growths can lead to seizures, strokes, hemorrhages, and other serious conditions, yet their precise molecular cause has never been determined. Now, cardiovascular scientists at the Perelman School of Medicine at the University of Pennsylvania have studied this pathway in heart development to discover an important set of molecular signals, triggered by CCM-linked gene defects, that potentially could be targeted to treat the disorder.
For small children, being hospitalized is an especially frightening experience above and beyond the challenges of whatever they are being treated for. They are often connected to a variety of unpleasant tubes and monitors, which they may instinctively try to remove.
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Graphene, a one-atom thick lattice of carbon atoms, is often touted as a revolutionary material that will take the place of silicon at the heart of electronics. The unmatched speed at which it can move electrons, plus its essentially two-dimensional form factor, make it an attractive alternative, but several hurdles to its adoption remain.
Doctoral student Johannes Eichstaedt of the School of Arts & Sciences says, “We now think of chronic stress as a chronic upregulation of the sympathetic nervous system.”