PHILADELPHIA — Calpain, a calcium-regulated enzyme, is essential to a host of cellular processes, but can cause severe problems in its overactivated state. It has been implicated as a factor in muscular dystrophy, AIDS, Alzheimer's disease, multiple sclerosis, and cancer. As such, finding and exploiting calpain inhibitors is an important area of research.
PHILADELPHIA – Nearly half of the 700,000 cancer patients who undergo surgical removal of a primary tumor each year suffer a recurrence of their disease at some point, and many of those patients will eventually die from their disease. The traditional view of recurrent tumors is that they are resistant to therapy because they’ve acquired additional genetic mutations that make them more aggressive and impervious to drugs.
La’Toya Latney’s grandmother has a photo from when Latney was about 5 years old. In it, she is sitting in front of the television, transfixed by a nature program on grizzly bears hunting salmon swimming upstream.
“At that time she said she knew I was going to be a veterinarian, so it’s been a long time coming for me,” says Latney.
PHILADELPHIA — The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death.
Susan Sorenson of the School of Social Policy & Practice shares her thoughts about the lack of funding for studies on guns.