PHILADELPHIA — LAM, short for pulmonary lymphangioleiomyomatosis, affects about 1 in 10,000 women of childbearing age and is characterized by proliferation of smooth muscle-like cells in the lung, destruction of lung tissue, and growth of lymphatic vessels. The disease is caused by inactivation of either of two genes, TSC1 or TSC2, but to date no animal model has been able to replicate the pathologic features those mutations produce in humans.
Robert Seyfarth is cited and Dorothy Cheney of the School of Arts and Sciences is quoted about their research involving baboon personalities.
Lee Sweeney of the Perelman School of Medicine comments on the results of a new experimental drug used with muscular dystrophy.
PHILADELPHIA — The hormone prolactin is produced by the pituitary gland in the brain and then travels via the bloodstream to cells throughout the body, where it exerts multiple reproductive and metabolic effects, most notably on the breast where it is the master regulator of lactation. In recent years researchers have found that prolactin is also produced by some tissues outside the brain, however little is known about the functions of extra-pituitary prolactin or how its production is regulated in these tissues.
PHILADELPHIA — Whether human or baboon, it helps to have friends. For both species, studies have shown that robust social networks lead to better health and longer lives. Now, a team of University of Pennsylvania researchers has helped show that baboon personality plays a role in these outcomes, and, like people, some baboons’ personalities are better suited to making and keeping friends than others.
PHILADELPHIA — We couldn’t live without our immune systems, always tuned to detect and eradicate invading pathogens and particles. But sometimes the immune response goes overboard, triggering autoimmune diseases like lupus, asthma or inflammatory bowel disease.
A new study led by University of Pennsylvania researchers has now identified a crucial signaling molecule involved in counterbalancing the immune system attack.