PHILADELPHIA — Most healthy cells rely on a complicated process to produce the fuel ATP. Knowing how ATP is produced by the cell’s energy storehouse – the mitochondria -- is important for understanding a cell’s normal state, as well as what happens when things go wrong, for example in cancer, cardiovascular disease, neurodegeneration, and many rare disorders of the mitochondria.
Penn Medicine Research: Pathway Identified in Human Lymphoma Points Way to New Blood Cancer Treatments
PHILADELPHIA — A pathway called the “Unfolded Protein Response,” or UPR, a cell’s way of responding to unfolded and misfolded proteins, helps tumor cells escape programmed cell death during the development of lymphoma.
Fran Barg of the Perelman School of Medicine comments on a grant Penn Medicine received from the NIH to study asbestos.
Garret FitzGerald and Kelly Allison of the Perelman School of Medicine are featured about research focusing on night eating.
PHILADELPHIA – Dorothy Roberts will deliver the keynote speech on “The Racial Geography of Child Welfare” at the Field Center for Children’s Policy, Practice & Research Winter 2012 Community Symposium at the University of Pennsylvania. Roberts, a Penn Integrates Knowledge Professor with appointments in law and sociology, will speak at 8:30 a.m., Wednesday, Nov.
What’s needed to ensure a solid future for the American worker?
According to one University of Pennsylvania researcher, it’s a matter of education and training. While not everyone is destined to attend college, it’s up to policymakers, employers and educators to team up to make sure that today’s students are prepared to meet the needs of tomorrow’s employers.
PHILADELPHIA — Electronic circuits are typically integrated in rigid silicon wafers, but flexibility opens up a wide range of applications. In a world where electronics are becoming more pervasive, flexibility is a highly desirable trait, but finding materials with the right mix of performance and manufacturing cost remains a challenge.
PHILADELPHIA — Just north of Philadelphia, the communities of West and South Ambler are working to recover from the ramifications of their town’s long-closed asbestos factory.
PHILADELPHIA — Fifty years ago, UK researcher John Gurdon demonstrated that genetic material from non-reproductive cells could be reprogrammed into an embryonic state when transferred into an egg. In 2006, Kyoto University researcher Shinya Yamanaka expanded on those findings by expressing four proteins in mouse somatic cells to rewind their genetic clocks, converting them into embryonic-like stem cells called induced pluripotent stem cells, or iPS cells.
Penn Medicine: Parkinson's Disease Protein Causes Disease Spread and Neuron Death in Healthy Animals
PHILADELPHIA — Understanding how any disease progresses is one of the first and most important steps towards finding treatments to stop it. This has been the case for such brain-degenerating conditions as Alzheimer's disease. Now, after several years of incremental study, researchers at the Perelman School of Medicine, University of Pennsylvania have been able to piece together important steps in how Parkinson’s disease (PD) spreads from cell to cell and leads to nerve cell death.