When Chyke Doubeni was in high school, he thought he might become an economist, like his older brother. But one day a teacher pulled him aside and noted that Doubeni, a new Presidential Term Professor at the University of Pennsylvania, had a talent for science. Perhaps he should consider a career in engineering or medicine instead, the teacher suggested.
PHILADELPHIA — Most healthy cells rely on a complicated process to produce the fuel ATP. Knowing how ATP is produced by the cell’s energy storehouse – the mitochondria -- is important for understanding a cell’s normal state, as well as what happens when things go wrong, for example in cancer, cardiovascular disease, neurodegeneration, and many rare disorders of the mitochondria.
PHILADELPHIA — The disease atherosclerosis involves the build up of fatty tissue within arterial walls, creating unstable structures known as plaques. These plaques grow until they burst, rupturing the wall and causing the formation of a blood clot within the artery. These clots also grow until they block blood flow; in the case of the coronary artery, this can cause a heart attack.
PHILADELPHIA — A new study by researchers at the Perelman School of Medicine at the University of Pennsylvania demonstrates in an animal model that a commonly used inhaled anesthetic drug, isoflurane, works by directly causing sleep-promoting neurons in the brain to activate, thereby hijacking our natural sleep circuitry.
PHILADELPHIA — Cutting the expenses associated with “low-value” medical tests and treatments – such as unnecessary imaging tests and antibiotics for viral infections that won’t benefit from them – will require a multi-pronged plan targeting insurance companies, patients, and physicians, according to a JAMA Viewpoint article published this week by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Stephen Morse of the Law School comments on research about neurolaw.
Penn Researchers Receive Grant to Explore Brain Training to Help Change Behaviors That Increase Cancer Risk
PHILADELPHIA — Most people know thatsmoking, a bad diet, and physical inactivity can lead to catastrophic personal health consequences, including cancer. Yet millions continue to smoke, eat poorly, and fail to get enough exercise. A new project led by researchers from the Perelman School of Medicine and the School of Arts and Sciences at the University of Pennsylvania aims to devise programs that help them change these risky behaviors and cut their risk of cancer.
A Mississippi River Diversion During the 2011 Flood Helped Build Louisiana Wetlands, Penn Geologists Find
PHILADELPHIA — The extensive system of levees along the Mississippi River has done much to prevent devastating floods in riverside communities. But the levees have also contributed to the loss of Louisiana’s wetlands. By holding in floodwaters, they prevent sediment from flowing into the watershed and rebuilding marshes, which are compacting under their own weight and losing ground to sea-level rise.
A gift from Joel and William Smilow to support Penn Medicine’s translational research activities is featured.