PHILADELPHIA — Electronic circuits are typically integrated in rigid silicon wafers, but flexibility opens up a wide range of applications. In a world where electronics are becoming more pervasive, flexibility is a highly desirable trait, but finding materials with the right mix of performance and manufacturing cost remains a challenge.
PHILADELPHIA — Just north of Philadelphia, the communities of West and South Ambler are working to recover from the ramifications of their town’s long-closed asbestos factory.
PHILADELPHIA — Fifty years ago, UK researcher John Gurdon demonstrated that genetic material from non-reproductive cells could be reprogrammed into an embryonic state when transferred into an egg. In 2006, Kyoto University researcher Shinya Yamanaka expanded on those findings by expressing four proteins in mouse somatic cells to rewind their genetic clocks, converting them into embryonic-like stem cells called induced pluripotent stem cells, or iPS cells.
Penn Medicine: Parkinson's Disease Protein Causes Disease Spread and Neuron Death in Healthy Animals
PHILADELPHIA — Understanding how any disease progresses is one of the first and most important steps towards finding treatments to stop it. This has been the case for such brain-degenerating conditions as Alzheimer's disease. Now, after several years of incremental study, researchers at the Perelman School of Medicine, University of Pennsylvania have been able to piece together important steps in how Parkinson’s disease (PD) spreads from cell to cell and leads to nerve cell death.
Penn Medicine: Yeast Protein Breaks up Amyloid Fibrils and Disordered Protein Clumps In Different Ways
PHILADELPHIA — Several fatal brain disorders, including Parkinson's disease, are connected by the misfolding of specific proteins into disordered clumps and stable, insoluble fibrils called amyloid. Amyloid fibrils are hard to break up due to their stable, ordered structure. For example, a-synuclein forms amyloid fibrils that accumulate in Lewy Bodies in Parkinson's disease. By contrast, protein clumps that accumulate in response to environmental stress, such as heat shock, possess a less stable, disordered architecture.
Ritesh Agarwal and Brian Piccione of the School of Engineering and Applied Science are featured for their study of manipulating the flow of light.
El Yunque Rock, an Icon of Puerto Rico, Is Eroding More Slowly Than Expected, Penn Geologists Discover
PHILADELPHIA — El Yunque rock is a majestic, anvil-shaped promontory that has been an icon of the island of Puerto Rico since pre-Columbian times. The barren rock, standing 3,412 feet high, protrudes above primary old growth forest and is enshrouded in clouds, swept constantly by the trade winds and frequently stricken by hurricanes. The rock receives an average of three rain showers a day and more than 14 feet of rain every year. Given Puerto Rico’s warm and dynamic tropical climate, El Yunque should be covered with vegetation and eroding rapidly.