John Trojanowski and Virginia Lee of the School of Medicine are cited for their innovative Alzheimer’s research.
Health & Medicine
Federal Grant Will Enable Netter Center’s Nutrition Program to Expand Service to More High School Students
AMP-activated protein kinase, or AMPK, is a master regulator protein of metabolism that is conserved from yeast to humans. When a cell is low on fuel, AMPK shuts down processes that use energy and turns on processes that produce energy.
Biologists have been studying how AMPK works for several decades and know that once it is activated, AMPK turns on a large number of genes by passing the "make more energy" message through numerous signaling cascades in the cell. What was not known, until now, was that AMPK also works via an epigenetic mechanism to slow down or stop cell growth.
Investigators have found that fruit fly (Drosophila melanogaster) males -- in which the activity of an Alzheimer’s disease protein is reduced by 50 percent -- show impairments in learning and memory as they age. What’s more, the researchers were able to prevent the age-related deficits by treating the flies with drugs such as lithium, or by genetic manipulations that reduced nerve-cell signaling.
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Seven faculty members in the University of Pennsylvania School of Veterinary Medicine are recipients of 2010 teaching awards.
Craig Umscheid of the School of Medicine and the Penn Medicine's Center for Evidence-Based Practice authors an op-ed on the consumer’s role in doctors’ prescription choices.
Susan Volk and Michael Atchison of the School of Veterinary Medicine discuss veterinarians’ role in translational research.