Health & Medicine

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Media Contact:Katherine Unger Baillie | kbaillie@upenn.edu | 215-898-9194April 22, 2015

Penn Vet, Montreal and McGill Researchers Show How Blood-Brain Barrier Is Maintained

blurb: 
In a new study, researchers have made insights into how the blood-brain barrier, or BBB, is maintained, identifying a protein key to the process. Delivering this protein to mice with the rodent equivalent of MS improved their symptoms.

The brain is a privileged organ in the body. So vital to life, the brain is protected from alterations elsewhere in the body by a highly regulated gateway known as the blood-brain barrier, which allows only selected molecules to pass through.

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Media Contact:Lee-Ann Donegan | leeann.donegan@uphs.upenn.edu | 215-349-5660April 17, 2015

Plasma Ap0A1 Associates with Age at Onset and Motor Severity in Early Parkinson’s Disease Patients, Penn Medicine Researchers Find

Building on previous research showing that plasma Apolipoprotein A1 (ApoA1) may be a useful biomarker for Parkinson’s disease, researchers from the Perelman School of Medicine at the Universit

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Media Contact:Lee-Ann Donegan | leeann.donegan@uphs.upenn.edu | 215-349-5660April 17, 2015
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Media Contact:Steve Graff | stephen.graff@uphs.upenn.edu | 215-349-5653April 19, 2015

Immunotherapy Drug Pembrolizumab Shows Early Promise for Mesothelioma Patients, Penn Medicine Researchers Find

The PD-1 inhibitor pembrolizumab, a cancer immunotherapy drug, shrank or halted growth of tumors in 76 percent of patients with pleural mesothelioma, a rare and deadly form of cancer that arises in the outer lining of the lungs and internal chest wall, according to a new study from researchers in the 

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Media Contact:Steve Graff | stephen.graff@uphs.upenn.edu | 215-349-5653April 19, 2015

New Combination of Immunotherapy Drugs is Safe, Shrinks Tumors in Metastatic Melanoma Patients, Penn Study Finds

Once again, researchers at Penn’s Abramson Cancer Center have extended the reach of the immune system in the fight against metastatic melanoma, this time by combining the checkpoint inhibitor tremelimumab with an anti-CD40 monoclonal antibody drug.

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Media Contact:Steve Graff | stephen.graff@uphs.upenn.edu | 215-349-5653April 19, 2015

Penn Medicine: Investigational Personalized Cellular Therapy Tolerated Well by Patients with Advanced Mesothelioma, Ovarian and Pancreatic Cancers

Genetically modified versions of patients’ own immune cells successfully traveled to tumors they were designed to attack in an early-stage trial for mesothelioma and pancreatic and ovarian cancers at the Per

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Media Contact:Karen Kreeger | karen.kreeger@uphs.upenn.edu | 215-349-5658April 20, 2015

Messenger RNA-associated Protein Drives Multiple Paths in T-cell Development, Penn Study Finds

RNA is both the bridge between DNA and the production of proteins that carry out the functions of life and what guides which and how much protein gets made.

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Media Contact:Karen Kreeger | karen.kreeger@uphs.upenn.edu | 215-349-5658April 16, 2015

Penn Study Describes First Steps in Basic Biological Process

Understanding the molecular signals that guide early cells in the embryo to develop into different types of organs provides insight into how tissues regenerate and repair themselves.

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Media Contact:Evan Lerner | elerner@upenn.edu | 215-573-6604April 15, 2015

Mentally Stepping Back From Problems Helps Youth Deal With Negative Emotions, Penn Study Says

Adolescence is a time of frequent and intense emotional experiences, but some youth handle their emotions better than others. Why do some young people react adaptively while others ruminate?

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Media Contact:Evan Lerner | elerner@upenn.edu | 215-573-6604April 15, 2015

Penn Senior Adrian Lievano to Tackle Water Security in Kenya

blurb: 
Building prosthetic limbs and developing rain-water filtration systems may seem like they have nothing in common. But to Adrian Lievano, a University of Pennsylvania senior from Miami majoring in mechanical engineering and applied mechanics, there’s a synergy: In both cases, the user is the designer’s top priority.

By Madeleine Stone @themadstone       

(This is the second in a series of features introducing the inaugural Penn President’s Engagement Prize winners.)