PHILADELPHIA –- Bioengineers at the University of Pennsylvania have created a system to control the flexibility of the substrate surfaces on which cells are grown without changing the surface properties, providing a technique for more controlled lab experiments on cellular mechanobiology, an important step in the scientific effort to understand how cells sense and respond to mechanical forces in their environment.
University of Pennsylvania School of Medicine researchers have described a previously unknown biological mechanism in cells that prevents them from cannibalizing themselves for fuel. The mechanism involves the fuel used by cells under normal conditions and relies on an ongoing transfer of calcium between two cell components via an ion channel. Without this transfer, cells start consuming themselves as a way of to get enough energy.
PHILADELPHIA -– The mechanism by which a herpes virus invades cells has remained a mystery to scientists, but now research from Tufts University and the University of Pennsylvania reveals the unusual structure of a key member of the protein complex that allows a herpes virus to invade cells.
The new map details an essential piece of the herpes virus “cell-entry machinery,” providing scientists with a new target for antiviral drugs.
PHILADELPHIA –- Researchers at the University of Pennsylvania have developed a new, carbon-based nanoscale platform to electrically detect single DNA molecules.
Using electric fields, the tiny DNA strands are pushed through nanoscale-sized, atomically thin pores in a graphene nanopore platform that ultimately may be important for fast electronic sequencing of the four chemical bases of DNA based on their unique electrical signature.
Sarah Tishkoff of the School of Medicine and the School of Arts and Sciences discusses “Jekyll-and-Hyde genetic variations."
PHILADELPHIA –- Collaboration by chemists, physicists and materials scientists at the University of Pennsylvania has created a simple and inexpensive method to rapidly grow centimeter-scale membranes of binary nanocrystal superlattices, or BNSLs, by crystallizing a mixture of nanocrystals on a liquid surface.
William James of the School of Medicine discusses sunscreen’s effectiveness.
Patrick McGovern of Penn Museum and the School of Arts and Sciences uses historical evidence to resurrect ancient brews.
David Barnes of the School of Arts and Sciences discusses the investigation of paranormal activity at the historic Lazaretto quarantine station.
Seven faculty members in the University of Pennsylvania School of Veterinary Medicine are recipients of 2010 teaching awards.