PHILADELPHIA –- Biologists at the University of Pennsylvania studying the processes of evolution appear to have resolved a longstanding conundrum: How can organisms be robust against the effects of mutations yet simultaneously adaptable when the environment changes?
Penn Study Shows Antidepressants Work Best for Severe Depression, Provide Little to No Benefit Otherwise
PHILADELPHIA –- A study of 30 years of antidepressant-drug treatment data published today in the Journal of the American Medical Association shows that the benefit of antidepressant medication compared with placebo may be minimal or nonexistent in patients with mild or moderate symptoms. University of Pennsylvania researchers say, however, the benefit of medications is substantial for patients with very severe depression.
Genetic Study Led by University of Pennsylvania and Cornell Clarifies African and African-American Ancestry
PHILADELPHIA –- People who identify as African-American may be as little as 1 percent West African or as much as 99 percent, just one finding of a large-scale, genome-wide study of African and African-American ancestry released today.
PHILADELPHIA –- Examining data obtained from a University of Pennsylvania and Vanderbilt University psychology study, researchers at these universities and Northwestern University have reported the first placebo-controlled evidence that antidepressant medications—particularly selective serotonin reuptake inhibitors, or SSRIs—can substantially change patients’ personalities. The personality changes also appeared to be linked to long-term improvements in mood.
PHILADELPHIA –- Reproductive researchers from the University of Pennsylvania and The Children’s Hospital of Philadelphia have succeeded in isolating and transplanting pure populations of the immature cells that enable male reproduction in two species—human spermatogonia and mouse gonocytes. These germline stem cells, taken from testis biopsies, demonstrated viability following transplantation to mouse testes within a controlled laboratory setting.