CHEMICAL AND BIOMOLECULAR ENGINEERING (EG) {CBE}
099. Undergraduate Research and Independent Study. (C) A maximum of 2 c.u. of CBE 099 may be applied toward the B.S.E degree requirements. An opportunity for the student to work closely with a professor in a project
to develop skills and technique in research and development. To register for this course, the student writes a one-page
proposal that is approved by the professor supervising the research and submitted to the undergraduate curriculum chairman
during the first week of the term.
111. Modern Engineering Problem Solving. (A) The application of computer tools to engineering problem solving.
L/R 150. Fundamentals of Biotechnology. (A) Principles of cell biology, biochemistry, and molecular biology will be summarized
from an engineering perspective, and examples of
biologically based molecular technologies and industrial
biochemical processes will be presented.
160. Introduction to Chemical Engineering. (B) This course will provide students with an introduction to analysis of processes
used in the chemical and pharmaceutical industries.
Emphasis will be placed on the development of flow
sheets and material balances for chemical processes.
Students wil also be introduced to modern process
simulation software.
L/R 230. Material and Energy Balances of Chemical Processes. (A) Prerequisite(s): CBE 160, Sophomore standing. Analysis of processes used in the chemical and pharmaceutical industries. Mass
and energy balances, properties of pure fluids, equations of state. Heat effects accompanying phase changes and chemical
reactions.
L/R 231. Thermodynamics of Fluids. (B) Holleran. Prerequisite(s): CBE 230. Thermodynamics and its applications to chemical processes; forms of energy and
their interconversion; phase and chemical equilibria; heat engines and thermal cycles.
L/R 350. Fluid Mechanics. (A) Hollaran. Prerequisite(s): CBE 231. Physical properties; fluid statics; Bernoulli equation; fluid kinematics; conservation
laws and finite control-volume analysis; conservation laws and differential analysis; inviscid flow; The Navier-Stokes
equation and some exact solutions; similitude, dimensional analysis, and modeling; flow in pipes and
channels; boundary layer theory; lift and drag.
L/R 351. Heat and Mass Transport. (B) Prerequisite(s): CBE 350. Steady-state heat conduction. The energy equation. Fourier's law. Unsteady-state
conduction. Convective heat transfer. Radiation. Design of heat transfer equipment. Diffusion, fluxes, and
component conservation equations. Convective mass transfer. Interphase mass transport coefficients.
L/R 353. Advanced Chemical Engineering Science. (A) Vohs, Gorte. Prerequisite(s): CBE 231. Applications of physical chemistry to chemical engineering systems. Equilibrium
statistical mechanics of ideal gases, dense fluids and interfacial phases. Chemical reaction rates. Collision and
transition state theories. Heterogeneous catalysis. Electronic structure and properties of solids.
371. Separation Processes. (B) Prerequisite(s): CBE 231. The design of industrial methods for separating mixtures. Distillation; liquid-liquid
extraction; membranes; absorption. Computer simulations
of the processes.
375. (ESE 360) Engineering and the Environment. (B) Prerequisite(s): Sophomore Standing. The principles of green design, life cylce
analysis, industrial ecology, pollution prevention
and waste minimization, and sustainable development
are introduced to engineers of all disciplines as
a means to identify and solve a variety of emerging environmental problems. Case studies are used to assess the problems
and devise rational solutions to minimize environmental
consequences.
L/R 400. Introduction to Process Design. (A) Seider. Prerequisite(s): CBE 371. Process synthesis, steady-state simulation, second-law analysis heat integration,
cost estimation and profitability analysis, plant-wide controllability assessment.
L/L 410. Chemical Engineering Laboratory. (A) Prerequisite(s): CBE 351, 371. Experimental studies in heat and mass transfer, separations and chemical reactors
to verify theoretical concepts and learn laboratory techniques. Methods for analyzing and presenting data. Report
preparation and the presentation of an oral technical report.
430. (CBE 510, MSE 430) Introduction to Polymer Science. (B) Prerequisite(s): BE 223, CBE 231, CHEM 221, MEAM203, MSE 260, or equivalent course in thermodynamics or physical chemistry.
Plastics, rubbers, proteins, epoxies, networks, and
such are polymeric materials, because all of these
materials have many ("poly") small repeat
units ("mers") covalently bonded together.
Polymers have unique physical properties and applications
due to their considerable molecular size, numerous
conformations and chemical variety. This course focuses
on physical and chemical properties and applications
of polymers in solution, the crystalline state, the
glassy state, and the rubbery state. Class demonstrations
and laboratory exercises. This introductory course
is intended for a broad cross-section of science
and engineering majors including bioengineers, chemical
engineers, chemists, mechanical engineers and materials
scientists.
440. (BE 440, BE 540, CBE 540) Biomolecular and Cellular Engineering. (C) This course provides an introduction to the quantitative methods used in characterizing
and engineering biomolecular properties and cellular
behavior, focusing primarily on receptor-mediated
phenomena. The thermodynamics and kinetics of protein/ligand
binding are covered, with an emphasis on experimental
techniques for measuring molecular parameters such
as equilibrium affinities, kinetic rate constants,
and diffusion coefficients. Approaches for probing
and altering these molecular properties of proteins
are also described, including site-directed mutagenesis,
directed evolution, rational design, and covalent
modification. Equilibrium, kinetic, and transport
models are used to elucidate the relationships between
the aforementioned molecular parameters and cellular
processes such as ligand/receptor binding and trafficking,
cell adhesion and motility, signal transduction,
and gene regulation.
L/R 444. (BE 444, BE 555, CBE 555, MEAM555) Nanoscale Systems Biology. (C) Prerequisite(s): Background in Biology, Chemistry or Engineering with coursework in thermodynamics
or permission of the instructor. From single molecule
studies to single cell manipulations, the broad field
of cell and molecular biology is becoming increasingly
quantitative and increasingly a matter of systems
simplification and analysis. The elaboration of various
stresses on cellular structures, influences of interaction
pathways and convolutions of incessant thermal motions
will be discussed via lectures and laboratory demonstration.
Topics will range from, but are not limited to, protein
folding/forced unfolding to biomolecule associations,
cell and membrane mechanics, and cell motility, drawing
from very recent examples in the literature. Frequent
hands-on exposure to modern methods in the field
will be a significant element of the course in the
laboratory. Skills in analytical and professional
presentations, papers and laboratory work will be
developed.
451. Chemical Reactor Design. (A) Prerequisite(s): CBE 231 and CBE 351. Design of reactors for the production of chemical products. Continuous and batch
reactors. Chemical kinetics. Effects of back-mixing and non-ideal flow in tubular reactors. Heterogeneous reactions.
Construction and economic analysis of reactors.
L/R 459. Process System Design Projects. (B) Prerequisite(s): CBE 400. Design of a chemical process based on recent advances in chemical engineering
technology. Weekly design meetings with faculty advisor and industrial consultants. Comprehensive design report
and formal oral presentation.
L/R 460. Chemical Process Control. (B) Prerequisite(s): CBE 353. Dynamics and control of linear single-input, single output (SISO) systems in
chemical processes. Laplace transforms. Dynamic responses of linear systems to inputs in time and transform domains.
Frequency domain analysis. Feedback control strategies. Stability. Controller tuning. Advanced control, including
cascade and feed forward control. Introduction to multiple-input, multiple-output (MIMO) control.
479. Biotechnology and Biochemical Engineering. (A) Prerequisite(s): CBE 150 or equivalent. Junior/Senior Standing in Engineering. An overview of several important aspects of modern biotechnology from a chemical
engineering perspective: DNA, enzymes and other biomolecules, cell growth and metabolism, cellular and enzymatic
reactors, bioseparation techniques, molecular genetics, and biotransport processes.
L/L 480. Laboratory in Biotechnology and Genetic Engineering. (C) Prerequisite(s): CBE 479 or Permission of the Instructor. Laboratory methods in biochemical and genetic engineering. Molecular cloning
techniques. DNA amplification and sequencing techniques. Culture of microbial cells. Recovery and purification
of a microbial product enzyme. Measurement of enzyme activity.
508. Probability and Statistics for Biotechnology. (L) This course is designed as an overview of probability and statistics including
linear regression, correlation, and multiple regression.
The program will also include statistical quality
control and analysis of variance with attention to
method of analysis, usual method of computation,
test on homogeneity of variances, simplifying the
computations, and multifactor analysis.
510. (CBE 430, MSE 430) Polymer Engineering. (B) This course focuses on synthesis, characterization, microstructure, rheology,
and structure-property relationships of polymers,
polymer directed composites and their applications
in biotechnology. Topical coverage includes: polymer
synthesis and functionalizaiton; polymerizaiton kinetics;
structure of glassy, crystalline, and rubbery polymers;
thermodynamics of polymer solutions and blends, and
crystallization; liquid crystallinity, microphase
separation in block copolymers; polymer directed
self-assembly of inorganic materials; biological
applications of polymeric materials. Case studies
include thermodynamics of block copolymer thin films
and their applications in nanolithography, molecular
templating of sol-gel growth using block copolymers
as templates; structure-property of conducting and
optically active polymers; polymer degradation in
drug delivery; cell adhesion on polymer surface in
tissue engineering.
520. Modeling, Simulations, and Optimization of Chemical Processes. (M) Nonlinear systems: numerical solutions of nonlinear algebraic equations; sparse
matrix manipulations. Nonlinear programming and optimization;
unconstrained and constrained systems. Lumped parameter
systems: numerical integration of stiff systems.
Distributed parameter systems: methods of discretization.
Examples from analysis and design of chemical and
biochemical processes involving thermodynamics and
transport phenomena.
521. Fundamentals of Industrial Catalytic Processes. (M) This course will introduce students to the important concepts invovled in industrial
catalytic processes. The first part of the course
will review some of the fundamental concepts required
to describe and characterize catalysts and catalytic
reactions. The majority of the course will then focus
on applying these concepts to existing heterogeneous
catalysts and catalytic reactions, including discussion
of the actual process design and engineering. Descriptions
of some homogeneously catalyzed processes like polymerization
and the synthesis of acetic acid will also be covered.
540. (BE 440, BE 540, CBE 440) Biomolecular and Cellular Engineering. (A) This course provides an introduction to the quantitative methods used in characterizing
and engineering biomolecular properties and cellular
behavior, focusing primarily on receptor-mediated
phenomena. The thermodynamics and kinetics of protein/ligand
binding are covered, with an emphasis on experimental
techniques for measuring molecular parameters such
as equilibrium affinities, kinetic rate constants,
and diffusion coefficients. Approaches for probing
and altering these molecular properties of proteins
are also described, including site-directed mutagenesis,
directed evolution, rational design, and covalent
modification. Equilibrium, kinetic, and transport
models are used to elucidate the relationships between
the aforementioned molecular parameters and cellular
processes such as ligand/receptor binding and trafficking,
cell adhesion and motility, signal transduction,
and gene regulation.
L/R 552. (BE 552) Cellular Bioengineering. (B) Application of chemical engineering principles to analysis of eukaryotic cell
biological phenomena, emphasizing receptor-mediated
cell function. Topics include receptor/ligand binding
kinetics and trafficking dynamics, growth factor
regulation of cell proliferation, cell adhesion,
cell migration and chemotaxis, and consequences of
these in physiological situations such as the immune
and inflammatory responses, angiogenesis, and wound
healing.
554. (BE 554) Engineering Biotechnology. (B) Advanced study of re DNA techniques; bioreactor design for bacteria, mammalian
and insect culture; separation methods; chromatography;
drug and cell delivery systems; gene therapy; and
diagnostics.
L/R 555. (BE 444, BE 555, CBE 444, MEAM555) Nanoscale Systems Biology. (A) Discher. Prerequisite(s): Background in Biology, Chemistry or Engineering with coursework in thermodynamics
or permission of the instructor. From single molecule
studies to single cell manipulations, the broad field
of cell and molecular biology is becoming increasingly
quantitative and increasingly a matter of systems
simplification and analysis. The elaboration of various
stresses on cellular structures, influences of interaction
pathways and convolutions of incessant thermal motions
will be discussed via lectures and laboratory demonstration. Topics will range from,
but are not limited to, protein folding/forced unfolding
to biomolecule associations, cell and membrane mechanics,
and cell motility, drawing from very recent examples
in the literature. Frequent hands-on exposure to
modern methods in the field will be a significant
element of the course in the laboratory. Skills in
analytical and professional presentations, papers
and laboratory work will be developed.
560. Biomolecular Engineering. (M) This course will cover current state of the art in engineering approaches to
design, optimization, and characterization of biomolecules.
Particular emphasis will be placed on proteins. Fundamental
physical biochemistry of biological macromolecules
will be reviewed to provide a basis for understanding
approaches to de novo protein design, combinatorial
directed evolution, methods for analysis of structure
and function, and practical applications for this
class of molecules. Much of the course material will
be drawn from the current literature.
L/R 562. (BE 562) Drug Discovery and Development. (A)
563. DEV&MANUF OF BIOPHARM. (C) New drug development and regulatory compliance related to small molecules and
biologics, overview of biopharma industry, regulation
and development process for new chemical entities
and biolgies, formulation of pharmaceutical dosage
forms, current Good Manufacturing Practices, chemistry
manufacture and controls, overview of Common Technical
Document (CTD), managing post-approval changes -
formulatin, process, packaging, and analytical.
617. (ESE 617, MEAM613) Control of Nonlinear Systems. (A) PID control of nonlinear systems; steady-state, periodic and chaotic attractors.
Multiple-input, multiple-output systems; decoupling
methods and decentralized control structures. Digital
control; z-transforms, implicit model control, impact
of uncertainties. Constrained optimization; quadratic
dynamic matrix control. Nonlinear predictive control.
Transformations for input/output linearized controllers.
L/R 618. (BE 662, MEAM662) Advanced Molecular Thermodynamics. (A) Review of classical thermodynamics. Phase and chemical equilibrium for multicomponent
systems. Prediction of thermodynamic functions from
molecular properties. Concepts in applied statistical
mechanics. Modern theories of liquid mixtures.
619. Application of Thermodyanics to Chemical Engineering II. (M) An introduction to statistical mechanics and its applications in chemical engineering.
Ensembles. Monatomic and polatomic ideal gases. Ideal
lattices; adsorption and polymer elasticity. Imperfect
gases. Dense liquids. Computer simulation techniques.
Interacting lattices.
621. Advanced Chemical Kinetics and Reactor Design. (A) Mechanisms of chemical reactions. Transition state theory. Langmuir-Hinshelwood
Kenetics. Absorption and cataysis. Simple and complex
reaction schemes. Design of idealized reactors. Fluidized
reactors. Solid-gas reactions. Residence time distributions.
Reaction and diffusion in solid catalysts. Reactor
stability and control.
L/R 640. (MEAM570) Transport Processes I. (A) The course provides an unified introduction to momentum, energy (heat), and
mass transport processes. The basic mechanisms and
the constitutive laws for the various transport processes
will be delineated, and the conservation equations
will be derived and applied to internal and external
flows featuring a few examples from mechanical, chemical,
and biological systems. Reactive flows will also
be considered.
641. Transport Processes II. (K) A continuation of CHE 640, with additional emphasis on heat and mass transport.
700. Special Topics. (M) Lectures on current research problems or applications in chemical engineering.
Recent topics have included heat transfer, polymer
science, statistical mechanics, and heterogeneous
catalysis.
701. Scattering Methods/Colloidal and Macromolecular Systems. (M) The scattering of light, x-rays and neutrons in (1) the characterization of
macromolecules in solution and the solid state, (2) the study of solid-state polymer morphology, and (3) the characterization of
inorganic, organic and biological systems of colloidal
dimensions. Both theory and experimental methods
will be covered.
702. Surface Science. (M) Techniques in surface science. Surface characterization techniques. Applications
to MOCVD, surface chemistry, and surface physics.
737. Biotechnology Seminar. (M)
899. Independent Study. (C)
990. Masters Thesis. (C)
995. Dissertation. (C)
999. Thesis/Dissertation Research. (C) For students working on an advanced research program leading to the completion
of master's thesis or Ph.D. dissertation requirements.
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