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Guidelines for Specific Procedures


If you require an exemption to any of the below Penn guidelines or policies, please submit the Exemption Request directly in ARIES (login and go to 'My submissions > Create', then click on "Exemption request").

Anesthetic Vaporizers & Gas Scavenging
Assigning Pain and Distress Levels to Animal Use Protocols 
Blood Collection - Common Sites for Blood Collection 
EAE and Other Demyelinating Diseases in Rodents 

Egg and Oocyte Harvest from Laboratory Frogs (Xenopus laevis) Updated 8/25/15

Euthanasia of Rodents New 8/25/15


Food and Fluid Regulation in Nonhuman Primates


Food and Fluid Regulation in Rodents
Humane Intervention and Endpoints for Laboratory Animal Species 
Large Animal Anesthesia and Analgesia Formulary 

Literature Search for Alternatives 


Monoclonal and Polyclonal Antibody Production
Mouse Anesthesia and Analgesia Recommendations

Mouse Breeding and Cage Density

Physical Restraint of Laboratory Animals for Experimental Purposes
Rapid Cooling to Induce Euthanasia of Zebrafish
Rat Breeding and Cage Density

Recordkeeping for USDA Species 


Rodent Genotyping Methods
Rodent Identification
Rodent Injections for Delivery of Experimental Agents

Rodent Survival Surgery 


Rodent Tumor and Cancer Models
Tribromoethanol Use in Mice & Rats 
Tricaine Methanesulfonate (MS-222) Preparation and Storage New 10/27/2015
USDA Species Surgery Guideline
Use Of Complete Freund's Adjuvant in Laboratory Animals    
Use of Neuromuscular Blocking Agents in Animals 


Species Specific Zoonoses Fact Sheets



Policies Related to the Animal Research Program

Adoption of University Animals
Animal Facilities 
Assuring Consistency Between Grants and Protocols
Canine Exercise and Socialization

Facility Visitation Updated 8/25/15    



Investigation of Animal Welfare Concerns

Management of Controlled Substances


Policy on Who May Be a Principal Investigator on a Protocol 

Post-Approval Monitoring 


Procurement of Animal Species (coming soon)
Protocol Review 
Recording Images of Research Animals 

Reporting Animal Welfare Concerns 


Satellite Housing


Social Housing 

Social Housing of Nonhuman Primates 

Training Requirements 

(Note that the above policy does not contain all appendices; Please see the complete policy on the ULAR website)

Use and Disposal of Expired Drugs or Materials

Use of Non-Pharmaceutical Grade Compounds 


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   Phone: 215.573.2540    Fax 215-573-9438.
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