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Guidelines And Policies


Protocol Preparation

The forms page will help you determine when and how to file the appropriate forms.


Preparing and Submitting a Protocol offers guidance.



Guidelines for specific procedures

If you require an exemption to any of the below Penn guidelines or policies, please complete an Exemption Form and submit to This e-mail address is being protected from spam bots, you need JavaScript enabled to view it for review.  If you protocol is in ARIES, please submit the Exemption Request directly in ARIES

Blood Collection  - Common Sites for Blood Collection 
Rodent Tumor and Cancer Models 
The Use Of Complete Freund's Adjuvant in Laboratory Animals
MonoClonal and Polyclonal Antibody Production
Food/Fluid Regulation in Rodents

Mouse Breeding and Cage Density 

Food and Fluids Regulation in Nonhuman Primates

Prolonged Restraint

Carbon Dioxide Euthanasia of Rodents


Egg and Oocyte Harvest from Laboratory Frogs (Xenopus Laevis) 

Rodent Survival Surgery 

Recordkeeping for USDA Species 

Anesthetic Vaporizers & Gas Scavenging
Mouse Anesthesia and Analgesia Recommendations
Tribromoethanol Use in Mice & Rats 
Assigning Pain and Distress Levels to Animal Use Protocols Updated 11/11/14

Literature Search for Alternatives 

EAE and Other Demyelinating Diseases in Rodents 
Rapid Cooling to Induce Euthanasia of Zebrafish 
Rodent Genotyping Methods Updated 11/25/14

Large Animal Anesthesia and Analgesia Formulary

Use of Neuromuscular Blocking Agents in Animals 
USDA Species Surgery Guideline 
Rodent Identification Updated 11/25/14
Humane Intervention and Endpoints for Laboratory Animal Species

Euthanasia of mouse and Rat Fetuses and Neonates

(For euthanasia of neonates 7 days or older, please refer to the Carbon Dioxide Euthanasia of Rodents guidelines)

Rodent Injections for Delivery of Experimental Agents 


Species Specific Zoonoses Fact Sheets




Policies related to the animal research program

Review and Investigation of Animal Welfare Concerns

Reporting Animal Welfare Concerns

Protocol Review New 11/25/14
Use and Disposal of Expired Drugs or Materials 

Use of Non-Pharmaceutical Grade Compounds New 11/25/14

Adoption Policy for University Animals
Facility Visitation (coming soon)

IACUC Policy on who may be a Principal Investigator on a Protocol

Taking, Storing and Destroying Compliance and Inspection Photographs
Procurement of Animal Species
Policy on Assuring Consistency Between Grants and Protocols
Canine Exercise and Socialization 
Social Housing of Nonhuman Primates
Policy on Animal Facilities

Policy on Satellite Housing 

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