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Guidelines for Specific Procedures


If you require an exemption to any of the below Penn guidelines or policies, please submit the Exemption Request directly in ARIES (login and go to 'My submissions > Create', then click on "Exemption request").

Anesthetic Vaporizers & Gas Scavenging
Assigning Pain and Distress Levels to Animal Use Protocols 
Blood Collection - Common Sites for Blood Collection 

Carbon Dioxide Euthanasia of Rodents

EAE and Other Demyelinating Diseases in Rodents 
Egg and Oocyte Harvest from Laboratory Frogs (Xenopus Laevis) 

Euthanasia of Mouse and Rat Fetuses and Neonates

(For euthanasia of neonates 7 days or older, please refer to the Carbon Dioxide Euthanasia of Rodents guidelines)

Food and Fluid Regulation in Nonhuman Primates

Food and Fluid Regulation in Rodents
Humane Intervention and Endpoints for Laboratory Animal Species 
Large Animal Anesthesia and Analgesia Formulary 

Literature Search for Alternatives 

Monoclonal and Polyclonal Antibody Production
Mouse Anesthesia and Analgesia Recommendations

Mouse Breeding and Cage Density

Physical Restraint of Laboratory Animals for Experimental Purposes
Rapid Cooling to Induce Euthanasia of Zebrafish
Rat Breeding and Cage Density

Recordkeeping for USDA Species 

Rodent Genotyping Methods
Rodent Identification
Rodent Injections for Delivery of Experimental Agents

Rodent Survival Surgery 

Rodent Tumor and Cancer Models
Tribromoethanol Use in Mice & Rats 
USDA Species Surgery Guideline
Use Of Complete Freund's Adjuvant in Laboratory Animals Updated 5/12/15  
Use of Neuromuscular Blocking Agents in Animals 


Species Specific Zoonoses Fact Sheets



Policies Related to the Animal Research Program

Adoption of University Animals
Animal Facilities 
Assuring Consistency Between Grants and Protocols
Canine Exercise and Socialization
Facility Visitation (under construction; coming soon)     
Investigation of Animal Welfare Concerns
Management of Controlled Substances
Policy on Who May Be a Principal Investigator on a Protocol 

Post-Approval Monitoring 

Procurement of Animal Species (coming soon)
Protocol Review 
Recording Images of Research Animals New 7/28/15

Reporting Animal Welfare Concerns 

Satellite Housing

Social Housing 

Social Housing of Nonhuman Primates 

Training Requirements 

(Note that the above policy does not contain all appendices; Please see the complete policy on the ULAR website)

Use and Disposal of Expired Drugs or Materials

Use of Non-Pharmaceutical Grade Compounds 

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