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Guidelines for Specific Procedures


If you require an exemption to any of the below Penn guidelines or policies, please submit the Exemption Request directly in ARIES (login and go to 'My submissions > Create', then click on "Exemption request").

Anesthetic Vaporizers & Gas Scavenging 
Assigning Pain and Distress Levels to Animal Use Protocols 
Blood Collection 


EAE and Other Demyelinating Diseases in Rodents 


Egg and Oocyte Harvest from Laboratory Frogs (Xenopus laevis) 
Euthanasia of Rodents 


Food and Fluid Regulation in Nonhuman Primates 


Food and Fluid Regulation in Rodents 
Humane Intervention and Endpoints for Laboratory Animal Species 
Large Animal Anesthesia and Analgesia Formulary 
Literature Search for Alternatives 


Monoclonal and Polyclonal Antibody Production 
Mouse Anesthesia and Analgesia Recommendations 
Mouse Breeding and Cage Density 
Physical Restraint of Laboratory Animals for Experimental Purposes 
Rapid Cooling to Induce Euthanasia of Zebrafish 
Rat Breeding and Cage Density 
Recordkeeping for USDA Species 


Rodent Genotyping Methods 
Rodent Identification  Updated 9/14/16
Rodent Injections for Delivery of Experimental Agents 
Rodent Survival and Terminal Surgery 


Rodent Tumor and Cancer Models 
Tribromoethanol Use in Mice & Rats 
Tricaine Methanesulfonate (MS-222) Preparation and Storage 
USDA Species Surgery 
Use of Complete Freund's Adjuvant in Laboratory Animals 
Use of Neuromuscular Blocking Agents in Animals  Updated 9/14/16


Species Specific Zoonoses Fact Sheets



Policies Related to the Animal Research Program

Adoption of University Animals 
Animal Facilities 
Assuring Consistency Between Grants and Protocols 
Canine Exercise and Socialization 
Facility Visitation 


Investigation of Animal Welfare Concerns 
Management of Controlled Substances  Updated 9/19/16


Policy on Who May Be a Principal Investigator on a Protocol 
Post-Approval Monitoring 


Procurement of Animal Species (coming soon)
Protocol Review 
Recording Images of Research Animals 
Reporting Animal Welfare Concerns 


Satellite Housing 


Social Housing 
Social Housing of Nonhuman Primates 
Training Requirements 

(Note that the above policy does not contain all appendices; Please see the complete policy on the ULAR website)

Use and Disposal of Expired Drugs or Materials 
Use of Non-Pharmaceutical Grade Compounds 


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