CHEMISTRY
(AS) {CHEM}
L/R 001. Introductory Chemistry I.
(A) Physical
World Sector. All classes. Corequisite(s): CHEM 051. Application
for permission must be submitted to the department.
Similar in coverage to Chemistry 101. This course explores
the basic concepts and principles of chemistry, with a greater
emphasis on problem solving. It is designed for students
with a lesser background in chemistry and/or mathe- matics. It
is suitable for chemistry majors, non-majors, or preprofessional
students.
L/R 012. Environmental Chemistry. (C) Physical World Sector. All classes.
The course requires math literacy at the high school algebra
level (2 years) and a willingness to learn Excel. Students
must also have taken one year of high school chemistry.
The course aims to teach chemical content and principles in
the context of significant environmental issues. Topics
to be covered include: composition of the atmosphere; protecting
the ozone layer; chemistry of global warming; traditional
hydrocarbon fuels and energy utilization; water supply, its
contaminants, and waste water treatment; acid rain; nuclear
energy; and new energy sources. Students will develop
critical thinking ability, competence to better assess risks
and benefits, and skills that will lead them to be able to
make informed decisions about technology-based matters.
L/R 015. Honors Chemistry I. (A) Physical
World Sector. All classes.
An advanced course for students who have had AP Chemistry
in high school. Included in the course coverage are: quantum
mechanics of atoms, molecules and crystalline solids; statistical
mechanics of gases, liquids, and solids; and coordination
chemistry.
SM 022. Structural Biology. (C) May be counted as a General Requirement
Course in Physical World. Class of 2009 & prior only.
Freshman Seminar.
This course will explain in non-mathematical terms how essentially
all biological properties are determined by the microscopic
chemical properties of proteins. It will also explain
how research results, especially those of structural biology,
are presented to its various audiences.
051. Introductory Chemistry Laboratory
I. (A) Corequisite(s):
CHEM 001. Lab fee $150. When a student enrolls simultaneously
in a laboratory course and a corequisite course, but subsequently
drops or withdraws from the corequisite course, the student
must drop or withdraw from the laboratory course.
An introductory laboratory course covering aspects of qualitative
and quantitative analysis, determination of chemical and
physical properties, and chemical synthesis.
L/L 053. General Chemistry Laboratory
I. (C) Corequisite(s):
CHEM 101. Lab fee $150. When a student enrolls simultaneously
in a laboratory course and a corequisite course, but subsequently
drops or withdraws from the corequisite course, the student
must drop or withdraw from the laboratory course.
A general laboratory course covering aspects of qualitative
and quantitative analysis, determination of chemical and
physical properties, and chemical synthesis.
L/L 054. General Chemistry Laboratory
II. (C) Corequisite(s):
CHEM 102. Lab fee $150. When a student enrolls simultaneously
in a laboratory course and a corequisite course, but subsequently
drops or withdraws from the corequisite course, the student
must drop or withdraw from the laboratory course.
Continuation of CHEM 053.
L/L 055. General Chemistry Laboratory
I for Freshmen. (A) Corequisite(s):
CHEM 101, Section 004. Lab fee $150. When a student
enrolls simultaneously in a laboratory course and a corequisite
course, but subsequently drops or withdraws from the corequisite
course, the student must drop or withdraw from the laboratory
course.
A general laboratory course covering aspects of qualitative
and quantitative analysis, determination of chemical and
physical properties, and chemical synthesis. This 0.5
c.u. lab course is an alternative to CHEM 053, but is only
open to freshman students who are also enrolled in the special
freshman section of CHEM 101 - Section 004.
L/L 056. General Chemistry Laboratory
II for Freshmen. (B) Corequisite(s):
CHEM 102, Section 001. Lab fee $150. When a student
enrolls simultaneously in a laboratory course and a corequisite
course, but subsequently drops or withdraws from the corequisite
course, the student must drop or withdraw from the laboratory
course.
Continuation of CHEM 055. This 0.5 c.u. lab course is
an alternative to CHEM 054, but is only open to freshman
students who are also enrolled in the special freshman section
of CHEM 102 - Section 001.
L/R 101. General Chemistry I. (C) Physical World Sector. All classes.
Corequisite(s): CHEM 053.
Basic concepts and principles of chemistry and their applications
in chemistry and closely-related fields. The first
term emphasizes the understanding of chemical reactions through
atomic and molecular structure. This is a university
level course, treating the material in sufficient depth so
that students can solve chemical problems and can understand
the principles involved in their solution. It includes
an introduction to condensed matter. This course is suitable
for majors or non-majors and is recommended to satisfy either
major or preprofessional requirements for general chemistry. This
course is presented for students with high school chemistry
and calculus. Students with a lesser background than this
should take Chemistry 1.
L/R 102. General Chemistry II. (C) Physical World Sector. All classes.
Prerequisite(s): CHEM 101. Corequisite(s): CHEM 054.
Continuation of Chemistry 101. The second term stresses
the thermodynamic approach to chemical reactions, electrochemical
processes, and reaction rates and mechanisms. It includes
special topics in chemistry.
L/R 221. Physical Chemistry I. (A) Prerequisite(s):
CHEM 102, MATH 114, PHYS 150.
Introductory quantum mechanics, atomic and molecular structure,
chemical bonding, and microscopic understanding of physical
and chemical properties of molecules.
L/R 222. Physical Chemistry II. (B) Prerequisite(s): CHEM 221, PHYS 151.
Continuation of CHEM 221. Principles and applications
of thermodynamics, and a molecular-based understanding of
macroscopic properties.
L/L 223. Experimental Physical Chemistry
I. (B) Prerequisite(s):
CHEM 221. Lab fee $300.
Important methods, skills, and apparatus used for the acquisition
and interpretation of quantitative information about chemical
systems will be discussed in principle and used in the laboratory.
L/R 241. Principles of Organic Chemistry.
(C) Prerequisite(s):
CHEM 102.
Fundamental course in organic chemistry based upon the modern
concepts of structure and mechanism of reactions.
L/R 242. Principles of Organic Chemistry.
(C) Prerequisite(s):
CHEM 241.
Continuation of CHEM 241.
L/L 245. Experimental Organic Chemistry
I. (C) Prerequisite(s):
CHEM 241. Corequisite(s): CHEM 242. Lab fee $300.
A basic laboratory course in which both the theoretical and
practical aspects of a variety of organic reactions and multistep
syntheses are emphasized. Modern chromatographic, instrumental,
and spectroscopic techniques are applied to experimental
organic chemistry. Course should be taken concurrently
with CHEM 242 or in the semester immediately following. For
safety reasons students will not be permitted to wear contact
lenses in the laboratory.
L/L 246. Experimental Organic Chemistry
II. (A) Prerequisite(s):
CHEM 242 and 245. Corequisite(s): CHEM 261. Lab fee $300.
Advanced laboratory work on the synthesis, structure, and
properties of organic compounds. Infrared, ultraviolet, and
nuclear magnetic resonance spectroscopy. Lectures cover the
theoretical basis and applications of modern spectroscopic
methods. For safety reasons students will not be permitted
to wear contact lenses in the laboratory.
251. Principles of Biological Chemistry.
(C) Prerequisite(s):
CHEM 102. Corequisite(s): CHEM 241.
Fundamentals of biological chemistry, including the structure
of biological macromolecules and their mechanism of action,
intermediary metabolism, and the chemical basis of information
transfer.
L/R 261. Inorganic Chemistry I. (A) Corequisite(s):
CHEM 241.
An introductory survey of the bonding, structure, and reactions
of important metal and nonmetal compounds.
299. Directed Study and Seminar.
(C) Prerequisite(s):
Permission of undergraduate chairman.
Directed study projects and seminars as individuals or small
groups under the supervision of a faculty member.
399. Independent Research. (C) Prerequisite(s): Permission of undergraduate
chairman; a B average in chemistry, mathematics, and physics.
Independent project under the direction of a faculty member.
441. Advanced Organic Chemistry:
Reactions, Mechanisms,and Stereoelectronic Effects. (A) Prerequisite(s): CHEM 242.
Study of important types of reactions and functional groups,
with emphasis on synthetic usefulness, mechanisms, and stereoelectronic
principles.
443. Modern Organic Synthesis.
(A) Prerequisite(s):
CHEM 241 and 242.
Introduction to advanced organic synthesis. Study of important
synthetic reactions including: oxidations, reductions, and
methods for the formation of carbon-carbon bonds, with an
emphasis in chemoselectivity, stereoselectivity and asymmetric
synthesis. Survey of modern methods for the synthesis of
small, medium and large ring systems. Analysis of modern
synthetic strategies, with illustrative examples from total
synthesis of natural and unnatural products.
451. Biological Chemistry I. (A) Prerequisite(s):
CHEM 242, 221 (may be concurrent), and 251 or permission
of instructor.
Structure, dynamics, and function of biological macromolecules. Properties
of macromolecular assemblies, membranes and their compartments. (Formerly,
CHEM 450-I).
452. Biological Chemistry II. (B) Prerequisite(s): CHEM 242, 221, and
251 or permission of instructor.
Physical and chemical description of macromolecular information
transfer. Gene organization, replication, recombination,
regulation and expression. (Formerly, CHEM 450-II).
462. Inorganic Chemistry II. (C) Prerequisite(s): CHEM 261 or its equivalent
and permission of instructor.
A detailed treatment of the theory and application of modern
physical methods for the elucidation of structure and mechanism
in inorganic and organometallic chemistry. An introduction
to symmetry and group theory is followed by the application
of these concepts to vibrational and electronic spectroscopy
of inorganic complexes. Magnetic resonance is discussed in
detail, including topics such as EPR, fourier transform methods,
dynamic systems, and 2-dimensional NMR.
521. Statistical Mechanics I. (A) Prerequisite(s):
CHEM 222.
Principles of statistical mechanics with applications to systems
of chemical interest.
522. Statistical Mechanics II.
(B) Prerequisite(s):
CHEM 521.
A continuation of CHEM 521. The course will emphasize
the statistical mechanical description of systems in condensed
phases.
523. Quantum Chemistry I. (A) Prerequisite(s):
CHEM 222.
The principles of quantum theory and applications to atomic
systems.
524. Quantum Chemistry II. (B) Prerequisite(s): CHEM 523.
Approximate methods in quantum theory and applications to
molecular systems.
525. Molecular Spectroscopy. (C)
A modern introduction to the theory of the interaction of
radiation and matter and the practice of molecular spectroscopy.
Conventional microwave, magnetic resonance, optical, photoelectron,
double-resonance, and laser spectroscopic techniques will
be included.
526. Chemical Dynamics. (B)
Theoretical and experimental aspects of important rate processes
in chemistry.
555. (BMB 554) Macromolecular Crystallography:
Methods and Applications. (A)
The first half of the course covers the principles and techniques
of macro- molecular structure determination using X-ray crystallography. The
second half of the course covers extracting biological information
from X-ray crystal structures with special emphasis on using
structures reported in the recent literature and presented
by the students.
557. Mechanisms of Biological Catalysis.
(C) Prerequisite(s):
One year of organic chemistry and a biochemistry course,
or permission of instructor.
Reaction mechanisms in biological (enzymes, abzymes, ribozymes)
and biomimetic systems with emphasis on principles of catalysis,
role of coenzymes, kinetics, and allosteric control.
559. Biomolecular Imaging. (B)
This course considers the noninvasive, quantitative, and repetitive
imaging of targeted macromolecules and biological processes
in living cells and organisms.Imaging advances have arisen
from new technologies, probe chemistry, molecular biology,
and genomic information. This course covers the physical
principles underlying many of the latest techniques, and
defines experimental parameters such as spatial and temporal
resolution, gain, noise, and contrast. Applications to cellular
and in vivo imaging are highlighted for confocal, two-photon,
and force microscopies; single-molecule, CARS, and fluorescence
correlation spectroscopy; FRET and fluorescence bleaching;
mass spectroscopy; MRI, PET and SPECT. The role of
molecular imaging agents comprised of proteins, organic or
inorganic materials is widely discussed.
564. Organometallics. (C)
This course is focused on molecular species that contain metal-carbon
bonds, and the role of these compounds in catalytic processes
and organic synthesis. Aspects of the synthesis, structure
and reactivity of important classes of organometallic compounds
such as metallo alkyl, aryl, alkene, alkylidene and alkylidyne
complexes are surveyed for the d and f block metals. Emphasis
is placed on general patterns of reactivity and recurring
themes for reaction mechanisms.
565. Main Group Chemistry. (C)
This course encompasses a comprehensive survey of the chemistry
and properties of the p-block elements of the periodic table.
Topics include syntheses, structures and reactivities of
important compounds. In addition, alternative bonding theories
which have been used to explain the unique properties of
these compounds are critically examined.
567. (BMB 567) Bio-inorganic Chemistry.
(C)
The course covers selected topics in bioinorganic chemistry;
special emphasis is placed on dioxygen chemistry and electron
transfer processes. Course topics include: (i) oxygen
uptake and utilization; (ii) diatomic oxygen trans port;
(iii) diatomic and monoatomic oxygen incorporation into substrates;
(iv) metalloenzyme-catalyzed C-C bond formation; (v) the
metallobiochemistry of DNA; (vi) metal-sulfide proteins;
(vii) manganese-containing metalloproteins; (viii) Photosystem
II: light-driven electron transfer and the biological water-splitting
reaction; (ix) biological electron transfer; (x) electron
transfer theory; (xi) mechanisms of energy storage and release;
and (xii) long-distance electron transfer reactions.
600. Tutorial Studies. (C) Both terms. May be repeated for credit
with permission of instructor.
Readings and discussion on various topics with various faculty members.
700. (BMB 700, PHRM630) Selected
Topics in Chemistry. (C)
May be repeated for credit and may be taken for multiple course
unit credit if more than one topic is offered in a term.
999. Independent Study and Research.
(C) May
be taken for multiple course unit credit.
(1) Advanced study and research in various branches of chemistry.
(2) Seminar in current chemical research. (3) Individual
tutorial in advanced selected topics.
Undergraduate BIOCHEMISTRY Courses
(BCHE)
299. Undergraduate Research Projects.
(C) 10-20
h., 1-2 c.u., admission by permission of the biochemistry
undergraduate chairman.
Independent Research.
300. Senior Research Projects. (C) 10-20 h., 1-2 c.u., admission by permission
of the biochemistry undergraduate chairman.
SM 404. Biochemistry Laboratory. (E) Year long course --initial registration
must occur in Fall term, 0 c.u. for first term and 2 c.u.
for second term, 10h. CHEM 451 or permission of instructor
required.
Independent research projects in the laboratories of individual
faculty members. A list of possible research supervisors
is available in the Biochemistry office (357 Chemistry). In
addition to their laboratory projects, students will attend
a weekly seminar in which their own and related work will
be discussed.
580.
(BCHE280, PHYS580) Biological Physics. (C) Prerequisite(s): Physics 150-151 or 170-171, Math 104-114
or Math 104-115. Recommended: concurrent Physics
230 or prior Physics 250, basic background in chemistry
and biology.
